Web3 Clara Parabricks - GenoBank.io & NVIDIA® Clara Parabricks™

AWS S3 Genomic Data Repository - Trio Analysis

Secure cloud storage for family genomic data

AUGenomics

Lab Director: Dr. Hannah Dose
LabNFT™ Wallet: 0xCcb8a7589B4ceB6f9e4c99D432b1511d049aeebd

Labs connect their AWS S3 buckets using their LabNFT™ wallet, enabling secure access to sequencing data

Private S3 Bucket

s3://augenomics-fastq/

Select Family Members from S3 Bucket

Mother Sample

Father Sample

Child Sample (Proband)

Encrypted genomic data accessible only through Web3 authentication

Select Trio Analysis Pipeline

Trio DeepVariant + GLnexus: Runs DeepVariant on each family member (mother, father, child) in parallel, then performs joint genotyping with GLnexus to identify inherited and de novo variants. This is a multi-step workflow, not a single command.

Trio Analysis Parameters

Model Type

Output Format

Detect De Novo Variants

Analyze Inheritance Patterns

Phase Variants

Min Mapping Quality

0 5 60

Min Base Quality

0 5 40

Min Fraction of Reads

0.0 0.05 1.0

Additional Quality Control

FASTQ Quality Control Pre-alignment QC with FastQC

BAM Quality Metrics Coverage, mapping, and alignment stats

VCF Quality Analysis Variant statistics and distribution

MultiQC Report Comprehensive QC summary

Coverage Analysis Depth and breadth of coverage

🧬 Tokenize resulting VCF as BioNFT™ on Story Protocol

as part of ꧁BioIP꧂ VCF Collection

Generated Command Preview:

pbrun deepvariant_germline --ref hg38.fasta --in-fq R1.fq.gz R2.fq.gz --out-variants output.vcf.gz --low-memory

Web3 GPU Accelerated Universal Genomics Analysis

GPU Turbo Engine

GPU Dashboard

Web3 Clara Parabricks by GenoBank.io

GPU-Accelerated

Web3 Secured

Trio Analysis

Serverless

System Status

AWS S3 Genomic Data Repository - Trio Analysis

Select Family Members from S3 Bucket

Previous Analysis Found

Trio Analysis Parameters

Generated Command Preview:

Active Processing Jobs

Download Processed Results

Sample Information

Available Files

Security Verification

Recently Completed Jobs

Family Trio Analyses 0

Individual Sample Analyses 0

Story Protocol Tokenization for Trio Results

Quality Control Metrics

Total Variants

-

Coverage

-

SNPs

-

Indels

-

Variant Type Distribution

Quality Score Distribution

Detailed Metrics

Live Processing Monitor

Analysis Results

Web3 GPU Accelerated Universal Genomics Analysis

GPU Turbo Engine

GPU Dashboard

Web3 Clara Parabricks by GenoBank.io

GPU-Accelerated

Web3 Secured

Trio Analysis

Serverless

System Status

AWS S3 Genomic Data Repository - Trio Analysis

Select Family Members from S3 Bucket

Previous Analysis Found

Trio Analysis Parameters

Reference & Known Sites

Output Options

Generated Command Preview:

Active Processing Jobs

Download Processed Results

Sample Information

Available Files

Security Verification

Recently Completed Jobs

Family Trio Analyses 0

Individual Sample Analyses 0

Story Protocol Tokenization for Trio Results

Quality Control Metrics

Total Variants

-

Coverage

-

SNPs

-

Indels

-

Variant Type Distribution

Quality Score Distribution

Detailed Metrics

Live Processing Monitor

Analysis Results